Beilstein J. Org. Chem.2014,10, 1151–1158, doi:10.3762/bjoc.10.115
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Keywords: labile linker; morpholinooligomers; oligonucleotide mimics; solid-phase-supported peptide synthesis (SPPS); Introduction
The phosphorodiamidate morpholinooligomers (PMO) and peptide conjugated PMO (PPMO) are currently promising candidates for antisense therapy of a number of infectious and
hereditary diseases [1][2][3][4] despite of some difficulties and limitations. They also proved to be valuable tools to study fundamental problems of gene expression in the course of embryogenesis [5][6]. A few examples of morpholinooligomers containing other types of internucleoside bonds were described
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Graphical Abstract
Figure 1:
Morpholinoglycine oligomers (A) and protected monomers 1a–e (B) for their synthesis.